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The event is being streamed at the Apple website under Apple-events/September-2017. London: 6PM, short films and full length movies.

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The program’s average accuracy at identifying the AUs was 67%, unprotected sex, they suggested. 2010 9:56 am Related News Upcoming singer and ‘shlf1314n Idol’ season five winner Sreeram Chandra has been roped in by Fox Star Studios shlf1314 in association with Sony Music for a special song in magnum opus ‘The Chronicles of Narnia: The Voyage of the Dawn Treader’. ?S. there are Krispy Kreme doughnuts" Church says the field only drew serious investment spawning new companies and new rivalries after a team led by Harvard’s Chad Cowan and Kiran Musunuru showed in the 4 April 2013 issue of Cell Stem Cell that CRISPR was far superior to existing genomeediting tools Scientists had harnessed and commercialized other enzymes for genome editing notably ones that relied on so-called zinc fingers and others known by the acronym TALENs (transcription activator-like effector nucleases) In the Cell Stem Cell paper the researchers did a head-to-head comparison of CRISPR and TALENs CRISPR they found was far more efficient at creating the targeted mutations "Up until that point CRISPR was just another scissors" says Church but now the new technique stood out Cowan and Musunuru teamed up with Church and Harvard’s Derrick Rossi who had recently co-founded a biotech Moderna Therapeutics that had broken records for investments They started to explore forming a CRISPR company "We talked to all the VCs in the space" says Musunuru now a cardiologist at the University of Pennsylvania Along the way they learned that Charpentier’s team and Zhang and his colleagues at Broad were also doing the VC dog-and-pony show "It was clear that people had competing interests even though the real issues didn’t come out to public display until later" Musunuru says Some scientists went their own way to make sure that they and not the investors would shape the companies whereas others hoped to make more money by affiliating with this or that VC firm "They were thinking the next Genentech—hundreds of millions of dollars" says Cowan of some of the earlier players who decided against launching a company with him And there were bruised relationships "It’s been an incredible fight over credit" Sontheimer says "Everyone is trying to jockey themselves and minimize what others did" By the end of 2013 Charpentier Novak Foy and Cowan had joined forces in CRISPR Therapeutics Zhang Church and Doudna helped co-found Editas Medicine which was born out of Broad Sontheimer Marraffini (now at The Rockefeller University in New York City) Rossi and Barrangou are all co-founders of Intellia Therapeutics Other pharmaceutical and biotechnology companies soon jumped in paying steep licensing and collaboration fees to the CRISPR startups as well as to Broad These companies stress that they have distinct development "pipelines" and business strategies But there’s a great deal of overlap: For example CRISPR Therapeutics and Editas have both made sickle cell disease and Duchenne muscular dystrophy a priority and Intellia and Editas both have programs targeting the liver disease α-1 antitrypsin deficiency and collaborations that focus on engineering T cells to fight cancer "At the 10000-foot level they’re all similar" Doudna says Yet she is unconcerned about duplication "There’s plenty of space in the gene-editing world for multiple entities" Charpentier notes that some redundancy is a good thing to solve tough biomedical problems "How many pharmaceutical industries and biotechs are working on the same thing" she asks *As of 9 February 2017 (Table data) SEC S-1 Filings The developing patent battle has led to further rifts Doudna Charpentier and collaborators—who collectively are represented by UC—first filed a patent application in May 2012 whereas the Broad group did not file a patent claim until that December But Broad which soon filed 11 more patents to support its central claim that Zhang’s team had invented the first CRISPR system to edit human cells paid USPTO to fast-track the review of its applications To the surprise of many in the field USPTO began issuing CRISPR patents to Broad in April 2014 before deciding on the UC Regents’ earlier patent application Church says he had serious misgivings about Broad’s patent position and the legal wrangling which Editas bankrolled "I almost quit" Church says Broad’s first patent application was rejected he says and Broad’s response to USPTO—in particular a declaration from Zhang—"was quite unfriendly and it questioned Jennifer’s veracity and authenticity" The declaration noted that Doudna acknowledged Church’s help in her January 2013 publication about making CRISPR work in human cells "I just thought she was being nice and holding that against her like she got vital information from me is odd" (Broad Editas and the other parties in the patent dispute refused to discuss the details) Doudna left Editas a few weeks after the patent was granted She says she had family commitments at home in Berkeley and was tired of traveling to Cambridge but adds "You’re welcome to draw your own conclusions" A year later she became a "cofounder" of Intellia—based in Cambridge And at UC’s behest USPTO declared a patent "interference" on 11 January 2016 which triggered an expensive contentious fight that the companies are financing The track record of earlier gene-editing approaches suggests that the CRISPR companies pursuing medical therapies have a long road ahead In 2009 for example Sangamo Therapeutics in Richmond California began using zinc finger nucleases to modify genes in immune cells from HIV-infected people hoping to make the cells resistant to the virus Yet the company still doesn’t have an approved therapy Similarly cancer immunotherapies designed with TALENs by Cellectis headquartered in Paris have been tested in people since 2015 but they’ve only been given to two patients so far There’s no reason to think CRISPR would succeed any faster in applications like those says Dana Carroll at the University of Utah in Salt Lake City who did pioneering work to develop the zinc finger technology "If you have just one target you’re going to hit over and over again and it’s part of a big project it doesn’t matter which platform you use" Carroll says "CRISPR’s a great advantage only when you’re feeling your way like you do in a research project" Nor is it clear that CRISPR will offer an easier path to genetically modified crops and livestock than other genetic engineering techniques do That will depend on whether government regulators exempt CRISPR-modified organisms which are made without transfering DNA from one species to another from the scrutiny that genetically modified organisms now get USPTO’s appeal board is expected to announce its decision in the next few weeks Sherkow and Contreras predict each party will likely wind up with some patent rights and will ultimately cross license But the decision is sure to shake up the industry Doudna says "It does raise this dilemma of what happens in the future with all of these various partnerships that have been put in place" she says "They will have to be re-evaluated" In spite of the uncertainties Barrangou who notes that for a decade he was one of only a handful of researchers working on CRISPR says people still underestimate how large CRISPR Inc will become "We’re not even getting started" he says "People say ‘I can’t wait for the bubble to burst’ Talk to them 6 months later and they say ‘I can’t believe this’ Talk to them 5 years later and they’ll still say they can’t believe it" Says Doudna: "She made various decisions about really going her own way with respect to her commercial involvement that I completely respect.a team member: “We would like to start clinical research within three to five years,say scientists who claim to have for the first time grown hair on hairless rodents in the laboratory. "We’ll just have to see" whether those incentives are sufficient.

who was murdered as a teenager while visiting relatives in Mississippi in 1955. 8:00 AM Deep in debt and struggling to provide for his family.