Yatra has introduced a new feature- ‘Xplore,’ making it easier to search and book holiday worldwide within your preferred budget. With this user friendly, easy to navigate and visually appealing feature, it aims to revolutionise and simplify the user experience while planning a holiday within a stipulated budget.In case, the traveller has chosen the holiday destination but is unaware of the cheapest time to travel, Xplore helps with this search too. In order to do so, the user just needs to enter the departure city followed by the destination. The user can then view the cheapest air fares available for the travel destination in a calendar format for each day of the month.The feature is currently available on Yatra’s mobile site and for desktops.
LOS ANGELES, CA – Continuing on a 20-year path of culinary innovation, luxury specialist Crystal Cruises has introduced its own Pinot Noir for 2010, according to a press release received by Elite Traveler.Crystal’s new 20th anniversary vintage joins the distinct cuvees comprising its “C” and “C” Reserve wine labels, including a 2005 Cabernet Sauvignon and Cabernet Sauvignon Reserve; 2005 Merlot and Merlot Reserve; and 2006 Chardonnay.Produced in the “C” Vineyard in California’s Santa Lucia Highlands, the 2010 Pinot Noir boasts flavors of strawberries and red cherries with earthy herbal undertones, and spicy aromas from French oak barrels. Crystal’s “C” wines were created to both complement the line’s fine a varied cuisine, as well as sate the palates of the most sophisticated connoisseurs.“The demand for Pinot Noir has soared in recent years, specifically for those from California’s coast,” says Toni Neumeister, vice president, food and beverage. “Given this demand, as well as the tremendous response to our existing variety of “C” Wines, our new Pinot Noir is a natural addition to Crystal’s extensive and diverse wine program.”To create the “C” wines, Neumeister worked closely with Crystal sommeliers, all certified by the Court of Master Sommeliers.Also created exclusively for Crystal to celebrate its platinum anniversary is a 20th Anniversary Billecart-Salmon Champagne, which is available on every 2010 Crystal voyage.Crystal’s culinary program boasts:* More than 20,000 bottles of 380+ vintages in the ships’ wine cellars,* More than 100 culinary classes and tastings offered each year,* More than 250 guest chefs, wine experts and mixologists during 15 years of Crystal’s popular Wine & Food Festival theme cruises,* Two specialty restaurants on each ship (Silk Road and The Sushi Bar) featuring the signature cuisine of Master Chef Nobu Matsuhisa,* Dozens of food and wine-focused Crystal Adventures ashore each year, including privately hosted chateau dinners in Bordeaux, cooking lessons in Barcelona and exclusive wine cellar tours in Sicily, and* Abundant fresh seafood, fruits and epicurean indulgences. More than 1,500 lbs. of caviar, 35,000 lbs. of fresh live lobster and 40,000 lbs. of strawberries are served on board annually.For more information and Crystal reservations contact a travel agent, call 888-799-4625, or visit www.crystalcruises.com. read more
Jet Aviation Dubai recently received maintenance approvals on Hawker 4000 and Global Express aircraft. Both approvals were obtained in response to strong customer demand; the first service appointment for each type of aircraft has already been received.The Dubai maintenance facility is an authorized service center for the Boeing 737 NG series (including BBJ), Gulfstream series, Dassault Falcon series as well as Hawker series aircraft, and an approved repair station for the Embraer Legacy.“Due to increased customer demand, we have expanded our services and can now better support also the first UAE Hawker 4000 operator as well as Global Express operators that demand MRO services from us. With the addition of these aircraft types we have extended our ’under-one-roof service offering‘ and our capability significantly,” says Michael Rücker, senior vice president and general manager of Jet Aviation Dubai.Jet Aviation’s Dubai maintenance and FBO location was established in May 2005. The facility has a total of 4,200 sq m (45,192 sq ft) of hangar space, a workshop area of 1,000 sq m (10,760 sq ft), and a two story FBO building with an area of 1,050 sq m (11,300 sq ft). Jet Aviation Dubai is certified by a variety of civil aviation authorities, including FAA (#U8JY426Y), Bermuda DCA, Cayman CAA, Pakistan CAA, Saudi Arabia PCA, and UAE GCAA. It is also an authorized dealer for Rockwell Collins avionics products as well as a Honeywell Authorized Mechanical Service Center.www.jetaviation.com read more
13Mar Rep. Alexander supports bills that give students better choice Categories: Alexander News,News State Rep. Julie Alexander of Hanover supports curriculum-based legislation that will give students more flexibility in their high school education choices to meet graduation requirements and prepare for a career.“Preparing students for life is a key mission of a high school education and these bills will help do that,” Alexander said. “If they have an aptitude in skilled trades, computer coding or statistics then they should be given the opportunity to explore the fields that align with their future aspirations and careers. Right now, employers are looking for workers in Jackson County who have the training and experience that we are giving students in our high schools.”The four bills are:Allow students to complete their 21st Century Skills requirement through a career/technical education (CTE) or visual/performing arts course.Allow for one foreign language course requirement to be met by completing a CTE or visual/performing arts course to graduate high school.Allow for statistics to be an alternative to Algebra II within current Michigan Merit Standards that require at least four mathematic credits to graduate.Allow for computer coding to be an alternative to a foreign language graduation requirement.House Bills 4315, 4316 and 4318 have been assigned to the House Workforce and Talent Development Committee. HB 4114 has been assigned to the House Education Reform Committee.##### read more
The Nautical Channel in Russia is changing its name to Morskoj (The Sea). The channel, which launched in the country in 2013 is available in Russia on the TV services of Megafon, Beeline, Rostelecom, Orion Express, MTC and TTK. It is also available via SPB TV’s service and on iOS platforms.Nautical Channel, which launched in 2011, is available in 30 countries internationally in English, French, German, Italian and Russian language versions.
North Carolina lawmakers have introduced legislation that aims to establish more teaching hospitals in rural areas. The legislation directs the N.C. Department of Health and Human Services to make recommendations establishing incentives to expand medical education in the state’s rural counties.Lawmakers would also like DHHS to identify medical centers that are ideal candidates to become teaching hospitals.According to The Winston-Salem Journal, the incentives would include loosening Medicare restrictions on which hospitals can provide medical teaching. The bill would also seek enticements for medical residents and students to remain in those rural areas after they graduate.The legislation is being submitted at a time when rural hospitals are struggling financially with reduced Medicare reimbursements.North Carolina currently has four main teaching hospitals, all located in urban centers. read more
Several cells have moved onshore with embedded rotation. Tornadoes are still possible across eastern North Carolina through Friday, where a Tornado Watch is in effect until further notice.Storm Surge Warnings continue for more than 350 miles of coastline from South Santee River, South Carolina, to Duck, North Carolina, including the Albemarle and Pamlico Sounds and the Neuse and Pamlico Rivers. Flood Warnings are in effect for multiple rivers, including the Pee Dee River At Cheraw in South Carolina where 10 to 20 inches of rainfall is likely due to Florence.As of 12 p.m. Friday, Florence was a Category 1 storm with winds up to 80 mph. The storm is forecast to continue slowing down as it encounters slower winds aloft. Florence will continue to weaken as it interacts with cooler waters due to upwelling near the coastline of North Carolina.The wind risk from Florence is greatest along the coast and along the northwestern side of the storm. Wind speeds are increasing in the Pee Dee region of South Carolina, and will move into the Mid-Carolina and Low-County regions on Saturday. Sustained winds up to 45 mph are possible, with gusts up to 60-70 mph. The wind damage risk from tropical-storm force winds will spread inland, likely as far as Charlotte and as far south as Charleston.Life-threatening storm surge of 9 to 13 feet is expected from Cape Fear to Cape Lookout, including the Neuse and Pamlico Rivers. The storm surge is likely to be in the 6 to 9-foot range from North Myrtle Beach to Cape Fear, and Cape Lookout to Ocracoke Inlet. Four to 6 feet of storm surge is forecast from South Santee River to North Myrtle Beach, and Ocracoke Inlet to North Carolina-Virginia Border. Two to 4 feet of water above normally dry ground can be anticipated from Edisto Beach to South Santee River.Catastrophic inland flooding will be a growing concern as Florence moves inland. Several Flash Flood Warnings are in effect across a large area of the Mid-Atlantic and Southern Appalachians.In some areas, the heavy rain risk could continue through next Tuesday. Due to the slow nature of the storm, Florence could produce up to 24 inches of rain near and north of where it comes ashore over a three or four-day period. Rainfall totals further inland may also be this high over a five-day period as the storm slowly weakens and meanders through North or South Carolina. Amounts this high could not only cause flash flooding, many rivers are likely to experience major – possibly even catastrophic -flooding for several days following Florence.Florence will continue to meander to the southwest, which means the potential for high winds and extreme rainfall could expand to include more of South Carolina.The South Carolina Emergency Information Network will continue to monitor the progress of Hurricane Florence and provide updates on public radio stations throughout the state, and on the @SCPublicRadio social media accounts. Hurricane Florence has slowed and is now crawling to the west at 6 mph. Life-threatening storm surge, inland flooding and wind damage are imminent along the coast of North Carolina from Wilmington to the Outer Banks and stretching to northern portions of South Carolina through the day on Friday. Florence is forecast to move southwest along the coastline before turning to the northeast on Sunday.An additional 15 inches of rain is expected for portions of southeastern North Carolina. As Florence moves inland, heavy rain and potential flooding will be a growing concern. By Saturday afternoon, rain will have entered the Pee Dee region of South Carolina with 4-10 inches forecasted. read more
December 12, 2014 The House of Representatives averted a government shutdown on Thursday, narrowly passing a $1.1 trillion spending bill despite strenuous Democratic objections to controversial financial provisions.The vote followed a long day of drama and discord on Capitol Hill that highlighted fraying Democratic unity and featured an uneasy alliance between President Barack Obama and House Speaker John Boehner, enemies in past budget battles but on the same side this time in pushing for passage.A vote on the measure was delayed for hours after Democrats revolted against provisions to roll back part of the Dodd-Frank financial reform law and allow more big money political donations, while conservative Republicans objected because the measure did not block funds for Obama’s immigration order.Democrats said Republican leaders, flexing their new political muscle after big wins in the midterm elections that will give them control of both chambers of Congress next year, had gone too far in trying to roll back Dodd-Frank.”We have enough votes to show them never to do this again,” Democratic House Leader Nancy Pelosi told members of her party, behind closed doors, according to a source in the room.Some Democrats also demanded the removal of a provision that allows a massive increase in individual contributions to national political parties for federal elections, potentially up to $777,600 a year.The debate pitted Obama against Pelosi, one of his most loyal allies in Congress, as Obama and his administration waged a last-ditch campaign to persuade Democrats to set aside their objections, arguing that if it failed, the party would get a worse spending deal next year under Republican control.The effort to save the bill angered some Democrats, who complained that both Obama and JPMorgan Chase & Co chief executive Jamie Dimon were calling Democrats to support it.”It is very strange, very strange that the two of them would be working for the support of this bill,” said Representative Maxine Waters, the top Democrat on the House Financial Services Committee.In the 219-206 vote, 67 Republicans rejected the spending bill, largely because it failed to take action to stop Obama’s executive immigration order. But that was offset by 57 Democrats who voted in favor.Shortly after passage, both the House and Senate passed a 48-hour extension to allow the Senate more time to consider the measure. Senate Democratic Leader Harry Reid said it would be debated on Friday.The 1,603-page bill, negotiated by Republican and Democratic appropriators and leaders, drew Democrats’ ire when they discovered it would roll back the Dodd-Frank law due to go into effect next year by killing planned restrictions on derivatives trading by large banks, allowing them to continue trading swaps and futures in units that benefit from federal deposit insurance and Federal Reserve loans.If passed by the Senate, the spending bill would fund all government agencies through September 2015, except for the Department of Homeland Security, which would get an extension only through Feb. 27. Republicans intend to deny funding to the agency to carry out Obama’s order allowing millions of undocumented immigrants to stay and work in the United States.The measure keeps domestic spending largely flat, while providing billions of dollars in additional funds to fight Islamic State militants in Iraq and Syria and the Ebola outbreak in West Africa.(Additional reporting by Susan Cornwell and Amanda Becker; Editing by John Whitesides, Tom Brown, Lisa Shumaker, Ken Wills and Simon Cameron-Moore) Next Article Government Shutdown 3 min read House Narrowly Passes Spending Bill, Averts U.S. Government Shutdown This story originally appeared on Reuters Free Webinar | July 31: Secrets to Running a Successful Family Business Learn how to successfully navigate family business dynamics and build businesses that excel. House Majority Leader Kevin McCarthy Reuters Image credit: Reuters | Larry Downing Add to Queue –shares Register Now » read more
Sponsored Content by BioLegendDec 14 2018 insights from industryDr. Peggy TaylorScientist & General ManagerBioLegendAn interview with Dr. Peggy Taylor (Sc.D.) at SfN 2018, discussing the biggest neurological research questions of today and how BioLegend is helping to develop new biomarkers for neurological disease.Why is it important to study neurological diseases?There are so many fundamental biological questions that remain unanswered about the functioning of the brain in health and disease states. That’s why we’re developing tools to try to enable people to interrogate pathways and processes to better understand how the brain works.Sebastian Kaulitzki | ShutterstockThe impact of diseases on the brain is very vast, from neurodegenerative diseases to psychiatric conditions. It impinges on a wide swathe of society, and the burden on society by these diseases is quite high. I think that neurological diseases are at the level of cancer in terms of the impact that they can have on people’s lives.What are the biggest neurological research questions being asked today?There are a lot of questions being asked right now, but I think that understanding the biology of synapses, how the brain is wired during development, and how those connections are maintained throughout life are some of the biggest questions.Misfolded proteins are the hallmarks of neurodegenerative disease, and we still don’t really understand why they form, how that happens, and why people are differently able to clear them. That goes right to the next thing, which is the genetics.There’s a lot of GWAS data out there and scientists trying to understand how that impacts certain cellular processes. Scientists are searching for commonalities, and if point mutations in disparate proteins impinge on the same processes.Neuroimmunology is another area that has emerged in the past few years. The link between aging, pro-inflammatory markers, and neurological disease is one particular area of interest. Researchers want to understand how inflammation impacts the ability of cells to maintain homeostasis and whether there are any protective mechanisms that can be exploited for new treatments.Over the last five to eight years, the research community has really started to understand that microglia and astrocytes – the resident immune cells of the brain – play a far greater role in neurological disease than previously thought, so there is a lot of biology to be understood here.People are also beginning to understand that the brain is not immune privileged, as they thought it had been for so many years, and so the role of infiltrating peripheral cells is a hot topic at the moment. How are biomarkers used in disease diagnosis, and why are new biomarkers needed for neurological diseases?The traditional definition of a diagnostic biomarker is where you can say, “If you have a reading of X number, that means you have this disease or you don’t,” but this is only a small sliver of how biomarkers can be used.Biomarkers can be used to stratify patients in clinical trials using their molecular profile and determine the intervention that is most suitable to them. There are so many different pathways that can result in a similar phenotype, especially in the field of neuroscience, so it’s important to understand the underlying cause of the disease and then identify the best course of action.Progression markers are also very important, not only for monitoring the patient’s health but also to understand if a therapy is working.The reason we need new biomarkers is that there’s a lot of crosstalk between neurodegenerative diseases. Traditional biomarkers may be able to distinguish healthy controls from somebody with a neurodegenerative disease, but getting into the specifics of who has which disease is an important part where we need new and better biomarkers.Imaging biomarkers have seen a rise in the last few years, and certainly being able to image amyloid and tau has greatly impacted the Alzheimer’s disease field. The Parkinson’s field is moving in that direction as well, where certain imaging technologies will be very impactful.Explode | ShutterstockHow is BioLegend involved in Parkinson’s disease research?As a leader in the life sciences industry, BioLegend is committed to the development of novel tools to enable researchers at the very basic level. A lot of neuroscience research relies on tissue staining, cell-based assays, western blots, and flow cytometry, and so it’s our goal to develop innovative and high-quality antibodies that can address those applications across the board in the areas we’ve mentioned, such as protein misfolding and autophagy.We have a long-standing relationship with the Michael J. Fox Foundation (MJFF), and as part of this, we supported the Parkinson Progression Markers Initiative through our Human α-Synuclein ELISA Kit. We’ve also done some analysis for the BioFIND Study and the S4 Study.We’re also working with key opinion leaders in the academic sector to develop new tools for some of the high priority targets that the MJFF has identified that we think will advance research for the PD community.What is the Covance antibody portfolio and why are custom antibodies invaluable for research?The Covance Antibody portfolio was acquired by BioLegend in 2014. Covance had built up an antibody products portfolio that was targeting areas of cell biology and neuroscience. This started with antibodies from Berkeley Antibody Company, Signet Laboratories, and Sternberger Monoclonals.Since the acquisition, BioLegend has been making investments to expand the portfolio and try to push the field forward with innovative and high-quality products.From the standpoint of custom antibodies, our approach is that we try to anticipate the needs of the research community. We have a team of scientists who are reading papers, coming out to meetings, watching big developments that are happening, and trying to project what will be needed.There are always cases where people are going to have a very specific target that they would like to engage using custom antibodies, and we love collaborating with labs to help make that happen.Where can readers find more information?Visit the BioLegend website to find out more.About Dr. Peggy TaylorDr. Taylor leads the Boston based business operations of BioLegend, Inc.Prior to joining BioLegend in 2014, Peggy was the Director of the Antibody Products business at Covance, where she had worked since 2004 leading the efforts of a development team producing and developing antibodies and immunoassays that are sold as research reagents. She has extensive experience in the development and commercialization of research reagents.Since 2008, Peggy has been working with the Michael J. Fox Foundation for Parkinson’s research to optimize and validate a total alpha-synuclein ELISA. As part of this, her laboratory has performed sample analysis in support of several programs designed to identify improved Parkinson’s disease biomarkers for diagnosis and disease progression (PPMI, BioFind, and S4).Peggy earned a Doctor of Science degree in cell biology from Harvard University and is a member of the Society for Neuroscience and the American Association for the Advancement of Science.Sponsored Content Policy: News-Medical.net publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments. Try It For Yourself:50% off Neuroscience Antibody Samples at BioLegend. read more
Reviewed by James Ives, M.Psych. (Editor)Feb 12 2019Rare mutations in the NTHL1 gene, previously associated with colorectal cancer, also cause breast cancer and other types of cancer. Researchers from Radboud university medical center, Leiden University Medical Center and the Princess Máxima Center in the Netherlands report this new multi-tumor syndrome, in collaboration with international colleagues, in Cancer Cell. Nicoline Hoogerbrugge, professor of Hereditary Cancer at Radboud university medical center: “We presumed to know all multi-tumor syndromes, but we have taken yet another step in identifying cancer genes.”Previously, Hoogerbrugge and colleagues showed that mutations in the NTHL1 gene lead to intestinal polyps that may develop into colorectal cancer. However, they observed that patients with mutations in this gene often have other types of cancer as well. In their publication, the researchers describe 17 families in which members of a single generation had mutations in the NTHL1 gene. Half of these patients developed various types of cancer during their lives, with breast cancer being particularly common.Mutations in the NTHL1 gene are very rare. A mutation in the NTHL1 gene only leads to cancer when the mutation is inherited from both parents. The researchers estimate that this is the case in about 1 in 115,000 people. The syndrome is difficult to detect because it only leads to cancer in a single generation of a family. Hoogerbrugge: “Currently, we already test patients with many intestinal polyps for mutations in the NTHL1 gene, but now we know that we should do this for more patients. Over the long term we want to screen for mutations in the NTHL1 gene in patients diagnosed with multiple cancers, as well as in patients that have brothers or sisters with multiple cancers.”Improved characterization of patients with mutations in the NTHL1 gene may lead to better assessment of their lifetime risk to develop certain types of cancer. “It is important for patients to be aware of their risk for breast cancer and also for me as a physician, so I can make recommendations,” says Maartje Nielsen, clinical geneticist at the Leiden University Medical Center. She recommends that patients with mutations in the NTHL1 gene should be screened for various types of cancer, including colorectal cancer and breast cancer.Mutation patternRelated StoriesHow cell-free DNA can be targeted to prevent spread of tumorsNanoparticles used to deliver CRISPR gene editing tools into the cellTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe researchers used a new method to determine that NTHL1 mutations also cause breast cancer and other types of cancer. This method is based on the fact that mutations in the NTHL1 gene cause a specific pattern of mutations in the DNA of the tumor. Because this pattern only occurs in tumors of patients with an NTHL1 mutation, and not in tumors from other patients, the researchers were able to link this pattern to the disrupted NTHL1 gene. In the future, this method can be used to detect new genetic causes of cancer. Roland Kuiper, molecular geneticist at the Princess Máxima Center: “More than 30 such mutation patterns are already described, which are not only specific for NTHL1 defects. If all the tumors in a patient with multiple types of cancer have the same mutation pattern, this is a strong indication that there is a genetic cause. This means that all these tumors developed in the same way.” Richarda de Voer, molecular biologist at Radboud university medical center, adds: “It has become increasingly difficult to find new cancer genes. By searching for mutation patterns in patients, we are able to take the next step in determining the genetic cause in more cancer patients.”NTHL1NTHL1 is involved in DNA repair. It recognizes a specific form of DNA damage. If a mutation occurs in the NTHL1 gene, there is no NTHL1 protein. Consequently, this specific form of DNA damage is not recognized and not repaired, leading to an accumulation of mutations, which causes cancer. Due to mutations in the NTHL1 gene, errors in the DNA where a ‘C’ is replaced by a ‘T’, are not corrected. These errors occur at specific locations in the DNA, resulting in a recognizable mutation pattern. Source:https://www.radboudumc.nl/en/ read more